Abstract: Standardized variant curation is essential for clinical care recommendations for patients with inherited disorders.Clinical Genome Resource (ClinGen) variant curation expert panels are developing disease-associated gene specifications using the 2015 American College of Medical Genetics and Genomics (ACMG) and Association for Molecular Pat
The Baffle bolts (BB) are components of the lower internals of the vessel of Pressurized Water Reactor (PWR) nuclear power plants.They are subjected to ultrasonic testing (UT) inspection as part of the Long-Term Operation (LTO) of the PWR plants worldwide.Unlike other areas undergo inspection, usually there are more than one thousand bolts in a typ
Abstract Background Understanding comorbidity and its burden characteristics is essential for policymakers and healthcare providers to allocate resources accordingly.However, several definitions of comorbidity burden can be found in the literature.The main reason for these differences lies in the available information about the analyzed diseases (i
I derive practical formulas for optimal arrangements between sophisticated stock market investors (continuous-time Kelly gamblers or, more generally, CRRA investors) and the brokers who lend them cash for leveraged bets on a high Sharpe asset (i.e., the market portfolio).Rather than, say, the broker posting a monopoly price for margin loans, the ga